Does arousal enhance apical amplification and disamplification?
نویسندگان
چکیده
We summarize evidence that input to the apical tufts of neocortical pyramidal cells modulates their response to basal input. Because this apical amplification and disamplification provide intracortical mechanisms for prioritization, Mather and colleagues' arguments suggest that their effects are enhanced by noradrenergic arousal. Though that is likely, it has not yet been adequately studied. Their article shows that it should be.
منابع مشابه
The effects of arousal on apical amplification and conscious state
Neocortical pyramidal cells can integrate two classes of input separately and use one to modulate response to the other. Their tuft dendrites are electrotonically separated from basal dendrites and soma by the apical dendrite, and apical hyperpolarization-activated currents (Ih) further isolate subthreshold integration of tuft inputs. When apical depolarization exceeds a threshold, however, it ...
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عنوان ژورنال:
- The Behavioral and brain sciences
دوره 39 شماره
صفحات -
تاریخ انتشار 2016